The following chemical classes are considered well studied with respect to their ability to inhibit tumor cell growth. Compounds in these calsses will not be considered for testing in the 60 cell line screen unless additional information is provided that indicates that the particular compound has significantly different biological activity than the known members of the class.
Anthracyclines
Ellipticines
Nucleosides
Nitrogen mustards
Metal-containing compounds
a-Halo Carbonyl Compounds
Podophyllotoxins
Nitrosoureas
Antifolates
Actinomycins
9-Aminoacridines
Thiosemicarbazones
Camptothecins
Quarternary ammonium salts
Taxanes
Possible student project: provide chemical structures, examples, and some background on these classes.
Well studied chemical classes
The following chemical classes are considered well studied with respect to their ability to inhibit tumor cell growth. Compounds in these calsses will not be considered for testing in the 60 cell line screen unless additional information is provided that indicates that the particular compound has significantly different biological activity than the known members of the class.
Possible student project: provide chemical structures, examples, and some background on these classes.